How are COPD exacerbations defined?
It can be challenging for patients to know how to manage their COPD and adopt sustainable self-management skills. All patients should be given the tools and support to:
In addition, patients with a high symptom burden or risk of exacerbation should be encouraged to take part in a pulmonary rehabilitation programme.1
Your patients may not pro-actively communicate changes to their symptoms during check-ups. New or worsening symptoms, and moderate or severe exacerbations, may necessitate a change in treatment.1 Conduct regular medication reviews to ensure patients are on the most appropriate therapy for them.
Many patients do not understand what COPD is, and more than half of patients are not familiar with words like “exacerbation”.16 When discussing COPD with your patients, adopting a shared language and using terms such as “attack” or “flare-up” can help patients to understand what has happened to them.
Talk to your patients about the importance of reporting exacerbations.
You can help patients identify and report their COPD exacerbations by downloading the Flare-up Checklist here.
The flare-up checklist is a tool to help patients identify if they might have had an exacerbation in the past 12 months, or if their symptoms might be worsening.
On completion, patients are encouraged to discuss their results with their healthcare professional for further guidance.
DOWNLOAD THE FLARE-UP CHECKLIST
Click here to revisit the GOLD definitions of Mild, Moderate and Severe COPD exacerbations.

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AstraZeneca stands in solidarity with the global respiratory community, both in the fight against COVID-19 and in ensuring patients get the accurate information they need to effectively manage their condition during this period.
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A COPD exacerbation is defined as ‘an event characterised by dyspnoea and/or cough and sputum that worsens in <14 days’.
A COPD exacerbation can be classified as:
Mild:
Dyspnoea (VAS <5), respiratory rate (<24 breaths/min), heart rate (<95 BPM), SpO2 (resting ≥92% breathing ambient air and ≤3% change) and serum CRP (<10 mg/L)1
Moderate:
Worsening of at least three of the five variables measured for a mild exacerbation1
Severe:
Same as a moderate exacerbation plus arterial blood gas values indicate hypercapnia and acidosis1
A history of exacerbations is the strongest predictor of future exacerbation risk. The risk of re-hospitalisation or death also increases substantially after a first severe COPD exacerbation, and with each subsequent event. 9,10
Poor lung function (i.e. FEV1) is associated with a greater risk of exacerbations. Patients with a higher FEV1 (GOLD Stage 1) may lose more lung function following an exacerbation than patients with more severe COPD.11
In patients with a history of exacerbations, a higher blood eosinophil count predicts an increased risk of future exacerbations.12
Patients with the highest symptom burden (i.e. a SGRQ score ≥60) have a 40% increase in risk of exacerbation and are twice as likely to be admitted to hospital.13
Patients with comorbidities such as lung cancer, heart failure, dyspepsia and asthma are at greater risk of experiencing frequent exacerbations.14